Research Article

Development and Characterization of Chalcone Derivatives Using 4-Hydroxyacetophenone and Anti-bacterial Activity against Two Pathogenic Bacterial Isolates From Women with Acute Urinary Tract Infections

Abstract

In this work, the synthesis of a series of chalcone analogs with 4-hydroxyacetophenone as skeleton is interesting. Compounds Chalcone derivatives 1, 2 and 3 were prepared by the condensation of 4-hydroxyacetophenone with N,N-imethylaminobenzaldehyde,3- methoxy4-hydroxybenzaldehyde,4-bromobenzaldehyde, respectively. The melting points of the synthesized compounds were determined and Fourier Transform Infrared (FT-IR) spectroscopy was carried out. The reaction was monitored by TLC using  benzene:methanol (4:1) as a solvent system to keep track of the order and measurement of the progress. The antibacterial activity of the chalcone derivatives was tested against two multidrugresistant aerobic pathogenic bacteria obtained from women with urinary tract infections. The resistant strains included both gram negative (Acinetobacter baumannii) and gram positive (Streptococcus pyogenes) bacteria. The activity was evaluated at four selected tested concentrations (25, 50, 100, and 150mg/ml) of each compound. Compound 3 showed the best antibacterial activity among other derivatives tested at 150 mg/mL concentration; inhibition zone diameters were attained at 20.450 ± 0.541 mm against Acinetobacter baumannii and 18.978 ± 0.600 mm against Streptococcus pyogenes.