Chronic Paraquat Exposure on Kidney and Vitamin E and C Treatment Benefits
- By Benjamin Nnamdi Okolonkwo, Clement Ugochukwu Nyenke, Doris Nnenna Ajibo, George-Opuda Maureen Ibitoroko, Kingsley Kalawari Odiabara - 31 Aug 2023
- Journal of Biomedicine and Biosensors, Volume: 3, Issue: 3, Pages: 3 - 10
- Received: May 29, 2023; Accepted: August 20, 2023; Published: August 31, 2023
The aim of this study was to evaluate the role of vitamin E and C in managing paraquat-inflicted kidney injury in rat. Exactly 120 rats were grouped A-D with 3 sub-groups (0, VE and VEC) of 10 rats each. All “0” subgroups were orally poisoned with paraquat increasing level of 0.0g/Kg, 0.02g/Kg, 0.04g/Kg and 0.06g/Kg for A, B, C and D respectively every two weeks for 3 months. All subgroup VE were orally treated with 500mg of vitamin E weekly for 3 months and all “VEC” subgroups were treated with 500mg of vitamin E and 2000mg/L of vitamin C weekly for 3 months. Blood samples and kidneys were collected at second and third months, the samples were assessed for kidney function. The results showed that singular vitamin E treatment and in combination with C restored renal function in paraquat-mediated nephrotoxicity in rats.