Research Article

Estimation of some Biochemical Markers in Patients with Metabolic Syndrome

Abstract

A collection of metabolic disorders, such as central obesity, insulin resistance, hypertension, and dyslipidemia, are known as metabolic syndrome. Together, these variables raise the risk of atherosclerosis, type II diabetes, and cardiovascular illnesses. The prevalence of MetS is rising globally, especially in populations undergoing lifestyle and dietary changes. This study aims to Analyze the relationship between MetS and various hematological and biochemical markers. Assess the role of Heat Shock Protein- 20 (HSP-20) as a potential biomarker for MetS. Compare metabolic indicators between MetS patients and a control group. The study was conducted at Al-Batul Hospital in Najaf Governorate and on 35 subjects, divided into two groups, 20 metabolic syndrome patients diagnosed based on obesity-related metabolic disorders and 15 healthy individuals as a control group. The ages of the participants ranged from 15 to 51years. However The results of the current study indicates a Participants were assessed based on the following parameters, Demographic characteristics: Age and Body Mass Index (BMI), Hematological markers: Hemoglobin (Hb), White Blood Cell count (WBC), and platelet count, Biochemical markers: Fasting Blood Sugar (FBS), cholesterol, triglycerides (TG), High-Density Lipoprotein (HDL), and Low-Density Lipoprotein (LDL), Blood pressure measurements: Systolic and diastolic pressures, HSP-20 levels, measured using ELISA techniques. The Current result show significant increase in mean level of age, BMI, FBS in patients with MetS compared with control group. The result also show there is no significant difference in mean level of blood pressure compared with control. The result also show significant increase in mean level of WBC, platelets, s. Cholesterol, TG, LDL of patients with MetS compared wih control and there is no significant difference in Hb and HDL of patients compared with control. The result show there is significant increase in mean level of HSP-20 of patient with MetS compared with control group. Conclusions: Metabolic syndrome is a complex condition with various metabolic abnormalities. Obesity, insulin resistance, and inflammation are key factors in its development. Addressing modifiable risk factors can aid in the prevention of metabolic syndrome. The study supports significant differences in demographics and risk factors between individuals with metabolic syndrome and healthy individuals. Metabolic Syndrome is a growing health concern linked to obesity and metabolic dysregulation. HSP-20 may serve as a novel biomarker for (MetS), though further research is needed. Lifestyle modifications, including: diet and exercise, are crucial in managing and preventing metabolic Syndrome. 

Authors affiliation:

Doaa Amer Kadhim: College of Science, Department of Pathological Analysis, University of Kufa. Iraq.

How To Cite: D.A. Kadhim. Estimation of some Biochemical Markers in Patients with Metabolic Syndrome. Journal of Biomedicine and Biosensors, 6(4):1–7, 2026. https://doi.org/10.58613/jbb641