Research Article

Inflammatory Biomarkers and Adiponectin in Post-COVID-19 Lung Fibrosis: Their Relationship with Disease Severity and Mortality

Abstract

Lung fibrosis was most commonly lung problem induced in a post-COVID patient. The present research was demonstrated the linked between concentration of circulating CRP, ESR and adiponectin that associated with severity and mortality of post COVID-19 patient with lung fibrosis. The current study was conducted by taking 25 patients with lung fibrosis attending Al-Kafel hospital in the province of Karbala. It was carried out from the age of the patient’s group was range from the 21-70 years. The information of patients was obtained through questionnaire consisted name, gender, age, weight, height. A group of 15 was considered healthy subjects. The result of current study showed there is significant increase in BMI in patients with PC (27.20 ± 0.9) when comparison to control. The result also, represented the percentage distribution of BMI of the patients with 24.57% normal weight, overweight 27.07% of the participants and about 29.9% suffered from obesity. The result in current study exhibits significant increase in inflammation characteristic (ESR and CRP concentration) in Post COVID 19 patients with lung fibrosis. Also, there is statistically significant increases in serum levels of Adiponectin (APN), in Post COVID 19 patients with Lung fibrosis in comparison with control. Conclusions: The present study offers an updated description of the biomolecule implications of APN in post COVID-19 with lung fibrosis and the high level of CRP to gather with elevated in ESR increased the risk for death in post COVID 19 patients with lung fibrosis. Elevated Adiponectin concentration was also correlation with an elevated rate of inflammation together with increase BMI.